The MSOT inVision is a powerful optoacoustic imaging system for small animal imaging. It acquires cross-sectional images, with high resolution, in vivo and in real time. The unique capability of the MSOT inVision to visualize and quantify optoacoustic contrast throughout the whole animal, from head to tail, makes it a very attractive choice for many scientists. Optionally, ultrasound computed tomography can add further insights.
The design of laser light illumination and acoustic signal detection is critical for attaining optimal visual and quantitative image quality. At the same time it is the area in which the optoacoustic commercially available imaging systems are most different.
The MSOT inVision features 360˚ ring illumination and 270˚ acoustic detection. This wide coverage angle is the basis for the full cross-sectional views of small animals and the unmatched tomographic image quality.
The MSOT inVision comes with a custom-design station for animal preparation. Key elements are an injection pad and an animal holder that allows repeatable positioning and anesthesia supply.
Animal preparation station
Workflow for imaging with the MSOT inVision
Following the positioning of the animal, the animal holder is inserted into the imaging chamber of the MSOT inVision. The software then facilitates fully automated image acquisition.
The MSOT inVision is controlled by viewMSOT, a software which covers the full imaging chain: from data acquisition to image reconstruction, spectral unmixing, visualization and quantification. Its comprehensive functionality enables users to analyze their data without the need for other software tools. viewMSOT also supports data export into a toolbox developed by iThera Medical, termed iLabs. This toolbox provides access to algorithms in beta development state and allows further advanced data analysis.
Introduction to viewMSOT software
Optoacoustic contrast of dye cleared in the kedney overlaid on ultrasound background image
The MSOT inVision 512-echo is the world’s only hybrid tomographic optoacoustic / ultrasound imaging system.
The integration of active ultrasound capability to the MSOT inVision adds complementary anatomical information.